Aortic stiffness is lower when PVAT is included: a novel ex vivo mechanics study-Reference-Cited by-同舟云学术

Aortic stiffness is lower when PVAT is included: a novel ex vivo mechanics study

Published:2022-06-01 Issue:6 Volume:322 Page:H1003-H1013
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Tuttle Tyler¹^ORCID,Darios Emma²,Watts Stephanie W.²^ORCID,Roccabianca Sara¹^ORCID

Affiliation:

1. Department of Mechanical Engineering, Michigan State University, East Lansing, Michigan

2. Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan

Abstract

We introduce a novel and physiologically relevant way of measuring perivascular adipose tissue (PVAT) mechanical stiffness which shows that PVAT’s low, yet measurable, stiffness is linearly correlated with the amount of collagen fibers present within the tissue. Including PVAT in the measurement of the aortic wall’s mechanical behavior is important, and it significantly affects the resulting metrics by decreasing aortic stiffness.

Funder

Michigan State University

HHS | NIH | National Heart, Lung, and Blood Institute

NSF | ENG | Division of Civil, Mechanical and Manufacturing Innovation

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00574.2021

Reference41 articles.

1. Modulation of Vascular Reactivity by Perivascular Adipose Tissue (PVAT)