A cell atlas of thoracic aortic perivascular adipose tissue: a focus on mechanotransducers-Reference-Cited by-同舟云学术

A cell atlas of thoracic aortic perivascular adipose tissue: a focus on mechanotransducers

Published:2024-05-01 Issue:5 Volume:326 Page:H1252-H1265
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Thompson Janice M.¹^ORCID,Watts Stephanie W.¹^ORCID,Terrian Leah²,Contreras G. Andres³^ORCID,Rockwell Cheryl¹^ORCID,Rendon C. Javier³^ORCID,Wabel Emma¹^ORCID,Lockwood Lizbeth¹,Bhattacharya Sudin¹²⁴⁵^ORCID,Nault Rance¹⁵^ORCID

Affiliation:

1. Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan, United States

2. Department of Biomedical Engineering, Michigan State University, East Lansing, Michigan, United States

3. Department of Large Animal Clinical Sciences, Michigan State University, East Lansing, Michigan, United States

4. Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, Michigan, United States

5. Institute for Integrative Toxicology, Michigan State University, East Lansing, Michigan, United States

Abstract

This study describes the atlas of cells in the thoracic aorta perivascular adipose tissue (taPVAT) of the Dahl-SS rat, an important hypertension model. We show that mechanotransducers are widely expressed in these cells. Moreover, PIEZO1 expression is shown to be restricted to the taPVAT and is functionally implicated in stress relaxation. These data will serve as the foundation for future studies investigating the role of taPVAT in this model of hypertensive disease.

Funder

HHS | NIH | National Heart, Lung, and Blood Institute

HHS | NIH | National Institute of General Medical Sciences

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00040.2024

Reference54 articles.

1. Influence of Perivascular Adipose Tissue on Rat Aortic Smooth Muscle Responsiveness

2. Perivascular Adipocytes Store Norepinephrine by Vesicular Transport

3. The influence of perivascular adipose tissue on vascular homeostasis

4. A New Function for Perivascular Adipose Tissue (PVAT): Assistance of Arterial Stress Relaxation

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