KV7 channels are potential regulators of the exercise pressor reflex-Reference-Cited by-同舟云学术

KV7 channels are potential regulators of the exercise pressor reflex

Published:2021-07-01 Issue:1 Volume:126 Page:1-10
ISSN:0022-3077
Container-title:Journal of Neurophysiology
language:en
Short-container-title:Journal of Neurophysiology

Author:

Wright Andrew B.¹,Sukhanova Khrystyna Yu.¹,Elmslie Keith S.¹

Affiliation:

1. The Baker Laboratory of Pharmacology, Department of Pharmacology, Kirksville College of Osteopathic Medicine, A.T. Still University of Health Sciences, Kirksville, Missouri

Abstract

KV7 channels control neuronal excitability. We show that these channels are expressed in muscle afferents and generate currents that are blocked by XE991 and bradykinin (BK). The XE991 block suggests that KV7 current comprises KV7.2/3 and KV7.5 channels. The BK inhibition of KV7 channels may explain how BK activates the exercise pressor reflex (EPR). Retigabine can enhance KV7 current, which could help control the inappropriately activated EPR in patients with cardiovascular disease.

Funder

HHS | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases

Publisher

American Physiological Society

Subject

Physiology,General Neuroscience

Link

https://journals.physiology.org/doi/pdf/10.1152/jn.00700.2020

Reference50 articles.

1. The Exercise Pressor Reflex

2. Muscle Afferent Receptors Engaged in Augmented Sympathetic Responsiveness in Peripheral Artery Disease

3. Role of the Exercise Pressor Reflex in Rats With Dilated Cardiomyopathy

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