In Vitro Effects of VA441, a New Selective Cyclooxygenase-2 Inhibitor, on Human Osteoarthritic Chondrocytes exposed to IL-1^|^beta;

Author:

Fioravanti Antonella,Tinti Laura,Pascarelli Nicola Antonio,Capua Angela Di,Lamboglia Antonello,Cappelli Andrea,Biava Mariangela,Giordani Antonio,Niccolini Silvia,Galeazzi Mauro,Anzini Maurizio

Publisher

Japanese Pharmacological Society

Subject

Pharmacology,Molecular Medicine

Reference52 articles.

1. 1 Zhang Y, Jordan JM. Epidemiology of osteoarthritis. Clin Geriatr Med. 2010;26:355–369.

2. 2 Vane JR. Inhibition of prostaglandin synthesis as a mechanism of action of aspirin-like drugs. Nat New Biol. 1971;231:232–235.

3. 3 Ofman JJ, Maclean CH, Straus WL, Morton SC, Berger ML, Roth EA, et al. A meta-analysis of severe upper gastrointestinal complications of nonsteroidal anti-inflammatory drugs. J Rheumatol. 2002;29:804–812.

4. 4 Brater DC. Anti-inflammatory agents and renal function. Semin Arthritis Rheum. 2002;32 Suppl 1:33–42.

5. 5 DeWitt DL. Cox-2-selective inhibitors: the new super aspirins. Mol Pharmacol. 1999;55:625–631.

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