Influence of cadmium and copper on tissue element levels of pregnant rats
Author:
Turgut Sebahat1, Enli Yaşar2, Emmungil Gülten1, Turgut Günfer1, Demir Süleyman2, Kaptanoglu Bünyamin2, Genç Osman1
Affiliation:
1. 1Department of Physiology, Faculty of Medicine, Pamukkale University, 20070, Denizli, Turkey 2. 2Department of Biochemistry, Faculty of Medicine, Pamukkale University, 20070, Denizli, Turkey
Abstract
AbstractIn the current study, we examined the effects of Cd on Cd, Cu, Zn and Fe levels in placenta and maternal and fetal plasma and tissues, the placental weight, total fetal and maternal body weights, and fetal and maternal tissue weights during pregnancy. A total of 21 adult female rats were treated during gestation with drinking water containing one of the following: 70 mg/L of CdCl2, a combination of 70 mg/L of CdCl2 and 70 mg/L of CuSO4, or no addition (control). Placenta Cu and Fe levels, fetal liver and kidney Cu levels, and fetal liver tissue weights were lower in the group administered Cd than in the control group. Also, Cd levels in the placenta, maternal and fetal liver, and maternal kidney were higher in the group treated with Cd than in controls. In the group administered both Cd and Cu, fetal body and tissue weights did not change, but Cd levels in the placenta, maternal and fetal liver, and maternal kidneys were higher than in controls. Zn and Fe levels in the maternal kidney and fetal liver were also lower in this group. Cd exposure during pregnancy resulted in Cd accumulation in maternal and fetal tissues during pregnancy and a decrease in the total weight of fetuses, and the combination of Cd and Cu caused some changes in the both maternal and fetal levels of Cu, Zn, and Fe, but it did not cause changes in the total fetal body weight or the weights of individual tissues.
Publisher
Walter de Gruyter GmbH
Reference33 articles.
1. D. Bagchi, M. Bagchi, S.J. Stohs, S.D. Ray, C.A. Kuszynski and H.G. Pruess: “Free radicals and grape seed proanthocyanidin extract: importance in human health and disease prevention”, Toxicology, Vol. 148, (2000), pp. 187–197. 2. D. Gunnarsson, G. Nordberg, P. Lundgren and G. Selstam: “Cadmium-induced decrement of the LH receptor expression and cAMP levels in the testis of rats”, Toxicology, Vol. 183, (2003), pp. 57–63. 3. L. Jarup, M. Berglund, C.G. Elinder, G. Nordberg and M. Vahter: “Health effect of cadmium-exposure: a review of the literature and a risk estimate”, Scand J. Work Environ. Health, Vol. 24, (1988), pp. 240–246. 4. N. Itoh, Y. Fujita, H. Nakanishi, Y. Kawai, T. Mayumi, G.S. Hwang, K. Min, S. Onosaka, N. Muto and K. Tanaka: “Binding of Cd to metallothionein in the placenta of Cd-treated Mouse”, J. Toxicol. Sci., Vol. 21, (1996), pp. 19–27. 5. C.E. Casey and P.A. Walravens: “Trace elements”, In: R.C. Tsang and B.L. Nichols editors, Nutrition during infancy, Philadelphia: Hanley & Belfus (1988), pp. 190–215.
Cited by
4 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
|
|