Effect of sea buckthorn meal extract in alleviating the toxic effect of ochratoxin A and zearalenone in porcine peripheral blood mononuclear cells

Abstract

Abstract The mycotoxins ochratoxin A (OTA) and zearalenone (ZEA) are frequent contaminants of cereals responsible for important toxic effects in human and animals. The aim of this study was to investigate the in vitro effect of the sea buckthorn meal extract in alleviating the toxic effect of ochratoxin A and zearalenone on oxidative stress and inflammation using porcine peripheral blood mononuclear cells. Our results have shown that both zearalenone and ochratoxin causes oxidative damage and alter the inflammatory response. The use of the sea buckthorn meal extract can improve some markers of the oxidative stress (total antioxidant status) and inflammation (pro-inflammatory cytokines IL-1β, TNF-α, IL-8, IL-6) altered by exposure to the mycotoxins ZEA and OTA and our results indicate that this waste represents a promising biological method that can be used for the alleviation of the mycotoxins negative effects.