Role of natural fatty acids in prophylaxis and treatment of cardiovascular diseases-Reference-Cited by-同舟云学术

Role of natural fatty acids in prophylaxis and treatment of cardiovascular diseases

Published:2022-09-01 Issue:3 Volume:68 Page:27-35
ISSN:2449-8343
Container-title:Herba Polonica
language:en
Short-container-title:

Author:

Niezgoda Joanna Teresa¹,Przerwa Filip²,Kukowka Arnold²,Aleksandrzak Justyna²,Kotrych Katarzyna³,Uzar Izabela⁴

Affiliation:

1. Medical Center Vita-Medica , Warsaw , Poland

2. Student Science Club Department of General Pharmacology and Pharmacoeconomics , Pomeranian Medical University in Szczecin , Szczecin , Poland

3. Department of General and Dental Radiology , Pomeranian Medical University in Szczecin , Szczecin , Poland

4. Department of General Pharmacology and Pharmacoeconomics , Pomeranian Medical University in Szczecin , Szczecin , Poland

Abstract

Summary Multiple randomized controlled trials (RCTs) have assessed the effects of supplementation with eicosapentaenoic acid (EPA) plus docosahexaenoic acid (DHA) known as omega-3 polyunsaturated fatty acids (FAs), commonly called fish oils, on the occurrence of cardiovascular diseases. In a living organism, omega-3 FA (EPA and DHA) and omega-6 FA (arachidonic acid [AA]) are also involved in the formation of key regulators of platelet aggregation, vasodilation and inflammation. It is important to know that EPA and DHA act in different ways on membrane structure and lipid metabolism. For this reason, combining DHA with EPA may modify the clinical effects of only EPA treatment. The effects of omega-3 FAs on cardiovascular system remain uncertain. Two recent negative trials of EPA + DHA, STRENGTH and OMEMI, have put the utility of omega-3 FAs in preventing atherosclerotic cardiovascular events under debate. This paper presents the actual knowledge on the role of polyunsaturated acids in cardiovascular diseases.

Publisher

Walter de Gruyter GmbH

Link

https://www.sciendo.com/pdf/10.2478/hepo-2022-0017

Reference38 articles.

1. 1. Karłowicz-Bodalska K, Bodalski T. Nienasycone kwasy tłuszczowe, ich właściwości biologiczne i znaczenie w lecznictwie. Post Fitoter 2007; 1:46-56.

2. 2. Materac E, Marczyński Z, Bodek KH, Rola kwasów tłuszczowych omega-3 i omega-6 w organizmie człowieka. Bromat Chem Toksykol 2013; XLVI, 2:225-233.

3. 3. Dutkowska A, Rachoń D. Rola kwasów tłuszczowych n-3 oraz n-6 w prewencji chorób układu sercowo-naczyniowego. Choroby Serca i Naczyń 2015; 12(3):154-159.

4. 4. Hooper L, Al-Khudairy L, Abdelhamid AS, Rees K, Brainard JS, Brown TJ, Ajabnoor SM et al. Omega-6 fats for the primary and secondary prevention of cardiovascular disease. Cochrane Database Syst Rev 2018; 11:CD011094. doi: https://dx.doi.org/10.1002/14651858.CD011094.pub410.1002/14651858.CD011094.pub4651679930488422

5. 5. Łoźna K, Kita A, Styczyńska M, Biernat J. Skład kwasów tłuszczowych olejów zalecanych w profilaktyce chorób cywilizacyjnych, Probl Hig Epidemiol 2012; 93(4):871-875.