Progress and Knowledge Transfer from Science to Technology in the Research Frontier of CRISPR Based on the LDA Model
Author:
Lyu Yushuang1, Yin Muqi2, Xi Fangjie1, Hu Xiaojun1
Affiliation:
1. Medical Information Center, and Department of Neurology of Affiliated Hospital 2 , Zhejiang University School of Medicine , Hangzhou , China 2. Institute of Cyber-Systems and Control , Zhejiang University School of Control Science and Engineering , Hangzhou , China
Abstract
Abstract
Purpose
This study explores the underlying research topics regarding CRISPR based on the LDA model and figures out trends in knowledge transfer from science to technology in this area over the latest 10 years.
Design/methodology/approach
We collected publications on CRISPR between 2011 and 2020 from the Web of Science, and traced all the patents citing them from lens.org. 15,904 articles and 18,985 patents in total are downloaded and analyzed. The LDA model was applied to identify underlying research topics in related research. In addition, some indicators were introduced to measure the knowledge transfer from research topics of scientific publications to IPC-4 classes of patents.
Findings
The emerging research topics on CRISPR were identified and their evolution over time displayed. Furthermore, a big picture of knowledge transition from research topics to technological classes of patents was presented. We found that for all topics on CRISPR, the average first transition year, the ratio of articles cited by patents, the NPR transition rate are respectively 1.08, 15.57%, and 1.19, extremely shorter and more intensive than those of general fields. Moreover, the transition patterns are different among research topics.
Research limitations
Our research is limited to publications retrieved from the Web of Science and their citing patents indexed in lens.org. A limitation inherent with LDA analysis is in the manual interpretation and labeling of “topics”.
Practical implications
Our study provides good references for policy-makers on allocating scientific resources and regulating financial budgets to face challenges related to the transformative technology of CRISPR.
Originality/value
The LDA model here is applied to topic identification in the area of transformative researches for the first time, as exemplified on CRISPR. Additionally, the dataset of all citing patents in this area helps to provide a full picture to detect the knowledge transition between S&T.
Publisher
Walter de Gruyter GmbH
Reference50 articles.
1. Arun, R., Suresh, V., Madhavan, C.E.V., & Murty, M.N. (2010). On Finding the Natural Number of Topics with Latent Dirichlet Allocation: Some Observations. In M.J. Zaki, J.X. Yu, B. Ravindran, & V. Pudi (Eds.), Advances in Knowledge Discovery and Data Mining, Pt I, Proceedings (Vol. 6118, pp. 391–402). Berlin: Springer-Verlag Berlin. 2. Baltimore, D., Berg, P., Botchan, M., Carroll, D., Charo, R.A., Church, G., … Yamamoto, K.R. (2015). A prudent path forward for genomic engineering and germline gene modification. Science, 348(6230), 36–38. doi:10.1126/science.aab1028 3. Blei, D.M., Ng, A.Y., & Jordan, M.I. (2003). Latent dirichlet allocation. Journal of Machine Learning Research, 3(4/5), 993–1022 4. Blei, D.M. (2012). Probabilistic topic models. Communications of the Acm, 55(4), 77–84. doi:10.1145/2133806.2133826 5. Blei, D.M., & Lafferty, J.D. (2006). Dynamic topic models. In Proceedings of the 23rd international conference on Machine learning (pp. 113–120).
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3 articles.
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