A prudent path forward for genomic engineering and germline gene modification

Author:

Baltimore David1,Berg Paul2,Botchan Michael34,Carroll Dana5,Charo R. Alta6,Church George7,Corn Jacob E.4,Daley George Q.89,Doudna Jennifer A.410,Fenner Marsha4,Greely Henry T.11,Jinek Martin12,Martin G. Steven13,Penhoet Edward14,Puck Jennifer15,Sternberg Samuel H.16,Weissman Jonathan S.417,Yamamoto Keith R.418

Affiliation:

1. California Institute of Technology, Mail Code 147-75, Pasadena, CA 91125, USA.

2. Stanford University School of Medicine, 291 Campus Drive, Stanford, CA 94305, USA.

3. University of California, Berkeley, 450 Li Ka Shing no. 3370, Berkeley, CA 94720-3370, USA.

4. Innovative Genomics Initiative, University of California, Berkeley, 188 Li Ka Shing Center, Berkeley, CA 94720-3370, USA.

5. Department of Biochemistry, University of Utah School of Medicine, 15 North Medical Drive East, Room 4100, Salt Lake City, UT 84112-5650, USA.

6. Department of Medical History and Bioethics, School of Medicine and Public Health, University of Wisconsin Law School, 975 Bascom Mall, Madison, WI 53706, USA.

7. Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.

8. Boston Children's Hospital, 300 Longwood Avenue, Karp Family Building, 7th Floor, Boston, MA 02115, USA.

9. Howard Hughes Medical Institute, 4000 Jones Bridge Road, Chevy Chase, MD 20815, USA.

10. Departments of Molecular and Cell Biology and Chemistry, Howard Hughes Medical Institute, 731 Stanley Hall, MS 3220, University of California, Berkeley, Berkeley, CA 94720-3220, USA.

11. Center for Law and the Biosciences, Crown Quadrangle 559 Nathan Abbott Way Stanford, CA 94305-8610, USA.

12. Department of Biochemistry, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland.

13. Department of Molecular and Cell Biology, College of Letters and Science, University of California, Berkeley, 210K Durant Hall, Berkeley, CA 94720-2920, USA.

14. Alta Partners, One Embarcadero Center, 37th Floor, San Francisco, CA 94111, USA.

15. Department of Pediatrics UCSF School of Medicine, 513 Parnassus Avenue, San Francisco, CA 94143, USA.

16. Department of Chemistry, 731 Stanley Hall, MS 3220, University of California, Berkeley, CA 94720-3220, USA.

17. Department of Cellular and Molecular Pharmacology, Howard Hughes Medical Institute, University of California, San Francisco, Byers Hall, 1700 4th Street, San Francisco, CA 94158-2330, USA.

18. UCSF School of Medicine, 600 16th Street, San Francisco, CA 94158, USA.

Abstract

A framework for open discourse on the use of CRISPR-Cas9 technology to manipulate the human genome is urgently needed

Funder

Caribou Biosciences, Inc.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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