Chloramphenicol-Induced Alterations in the Liver and Small Intestine Epithelium in Pigs-Reference-Cited by-同舟云学术

Chloramphenicol-Induced Alterations in the Liver and Small Intestine Epithelium in Pigs

Published:2018-05-01 Issue:2 Volume:18 Page:429-440
ISSN:2300-8733
Container-title:Annals of Animal Science
language:en
Short-container-title:

Author:

Klebaniuk Renata¹,Tomaszewska Ewa²,Dobrowolski Piotr³,Kwiecień Małgorzata¹,Burmańczuk Artur⁴,Yanovych Dmytro⁵,Zasadna Zvenyslava⁵,Szymańczyk Sylwia²,Burmańczuk Natalia²,Muszyński Siemowit⁶

Affiliation:

1. Institute of Animal Nutrition and Bromatology, University of Life Sciences in Lublin, Akademicka 13, 20-950 Lublin , Poland

2. Department of Animal Physiology, University of Life Sciences in Lublin, Akademicka 12, 20-950 Lublin , Poland

3. Department of Comparative Anatomy and Anthropology, Maria Curie-Skłodowska University, Akademicka 19, 20-033 Lublin , Poland

4. Sub-Department of Pharmacology, Department of Preclinical Veterinary of Sciences, University of Life Sciences in Lublin, Akademicka 12, 20-950 Lublin , Poland

5. Laboratory of Instrumental Methods of Analysis, The State Scientific Research Control Institute of Veterinary Medicinal Products and Feed Additives (SCIVP), Donetska 11, 79019 Lviv , Ukraine

6. Department of Physics, University of Life Sciences, Akademicka 13, 20-950 Lublin , Poland

Abstract

Abstract An effect of the exposure to chloramphenicol (CAP) at doses used therapeutically was studied in pigs at the age of slaughter. Pigs were treated with CAP intramuscularly (20 mg/kg b.w. two times every 24 hours). Histomorphometrical and immunohistochemical analyses of small intestine and liver were done. CAP increased the thickness of myenteron and submucosa, and the length of villi; decreased the depth of crypts in the duodenum and jejunum. CAP influenced the Auerbach plexus. A decrease in cell proliferation, an increase in the number of apoptotic cells and T lymphocytes in the CAP-treated pigs were observed. CAP induces hepatotoxicity, neurotoxicity and disturbed intestinal epithelium. It can be concluded that short exposure of pigs to CAP at doses used therapeutically results in disturbed digestion and absorption process in the intestine.

Publisher

Walter de Gruyter GmbH

Link

https://www.sciendo.com/pdf/10.2478/aoas-2018-0001

Reference42 articles.

1. Abu Eid R., Landini G. (2003). Quantification of the global and local complexity of the epithelialconnective tissue interface of normal, dysplastic, and neoplastic oral mucosae using digital imaging. Pathol. Res. Pract., 199: 475-482.

2. Ahmadizadeh M., Esmailpoor M., Goodarzi Z. (2013). Effect of phenobarbital on chloramphenicol- induced toxicity in rat liver and small intestine. Iran J. Basic Med. Sci., 16: 1282-1285.

3. Berendsen B., Stolker L.,de Jong J., Nielen M., Tserendorj E., Sodnomdar- jaa R., Cannavan A., Elliott C. (2010). Evidence of natural occurrence of the banned antibiotic chloramphenicol in herbs and grass. Anal. Bioanal. Chem., 397: 1955-1963.

4. Brady N.C., Weil R.R. (2002). The nature and properties of soils. Upper Saddle River, USA, Prentice Hall, 13th ed., 960 pp.

5. Cannon M., Harford S., Davies J.A. (1990). Acomparative study on the inhibitory actions of chloramphenicol, thiamphenicol and some fluorinated derivatives. J. Antimicrob. Chemother., 26: 307-317.

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