Author:
Danilevičius P.,Žukauskas A.,Bičkauskaitė G.,Purlys V.,Rutkauskas M.,Gertus T.,Paipulas D.,Matukaitė J.,Baltriukienė D.,Malinauskas M.
Abstract
Laser-Micro/Nanofabricated 3D Polymers for Tissue Engineering ApplicationsA multi-photon polymerization system has been designed based on a pulsed irradiation light source (diode-pumped solid state femtosecond laser Yb:KGW, 300 fs, 1030 nm, 1-200 kHz) in combination with large working area and high precision linear motor driven stages (100×100×50 mm3). The system is intended for high resolution and throughput 3D micro- and nanofabrication and enables manufacturing the polymeric templates up to 1 cm2areas with sub-micrometer resolution. These can be used for producing 3D artificial polymeric scaffolds to be applied for growing cells, specifically, in the tissue engineering. The bio-compatibility of different acrylate, hybrid organic-inorganic and biodegradable polymeric materials is evaluated experimentallyin vitro. Variously sized and shaped polymeric scaffolds of biocompatible photopolymers with intricate 3D geometry were successfully fabricated. Proliferation tests for adult rabbit myogenic stem cells have shown the applicability of artificial scaffolds in biomedicine practice.
Subject
General Physics and Astronomy,General Engineering
Reference52 articles.
1. Materials processing: two-photon fabrication;M. Farsari;Nat. Photonics,2009
2. Two-photon polymerization: a new approach to micromachining;A. Ostendorf;Photon. Spectra,2006
3. 22-nm half-pitch extreme ultraviolet node development as the SEMATECH Berkeley microfield exposure tool;P. Naulleau;Microelectron. Eng,2009
4. Sunne, G.R. (2008). Electron beam lithography for nanofabrication. PhD thesis, University of Barcelona (Barcelona), 17-21.
5. Nanoimprint lithography: an old story in modern times? (a review);H. Schift;J. Vac. Sci. Technol,2008
Cited by
6 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献