Synthesis and pharmacological properties of 3-(2-methyl-furan-3-yl)-4-substituted-Δ2-1,2,4-triazoline-5-thiones-Reference-Cited by-同舟云学术

Synthesis and pharmacological properties of 3-(2-methyl-furan-3-yl)-4-substituted-Δ2-1,2,4-triazoline-5-thiones

Published:2008-03-01 Issue:1 Volume:6 Page:47-53
ISSN:2391-5420
Container-title:Open Chemistry
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Author:

Siwek Agata¹,Wujec Monika¹,Dobosz Maria¹,Jagiełło-Wójtowicz Ewa²,Chodkowska Anna²,Kleinrok Agnieszka²,Paneth Piotr³

Affiliation:

1. 1Department of Organic Chemistry, Faculty of Pharmacy, Medical University, Staszica 6, 20-081, Lublin, Poland

2. 2Department of Toxicology, Medical University, 20-093, Lublin, Poland

3. 3Department of Computer Science, Academy of Humanities and Economics in Lodz, 90-222, Lodz, Poland

Abstract

AbstractBy the reaction of 2-methyl-furan-3-carboxylic acid hydrazide with isothiocyanates, 1-[(2-methyl-furan-3-yl)carbonyl]-4-substituted thiosemicarbazides 1 were obtained. Further cyclization with 2% NaOH led to the formation of 3-(2-methyl-furan-3-yl)-4-substituted-Δ2-1,2,4-triazoline-5-thiones 2. The pharmacological effects of 2 on the central nervous system in mice were investigated. Strong antinociceptive properties of the investigated derivatives were observed in a wide range of doses.

Publisher

Walter de Gruyter GmbH

Subject

Materials Chemistry,General Chemistry

Link

http://link.springer.com/content/pdf/10.2478/s11532-007-0058-0.pdf

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