Extraction of B12 Reference Intervals from a Large Amount of General Patient Data-Reference-Cited by-同舟云学术

Extraction of B12 Reference Intervals from a Large Amount of General Patient Data

Published:2022-06-01 Issue:3 Volume:76 Page:333-337
ISSN:2255-890X
Container-title:Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.
language:en
Short-container-title:

Author:

Gavars Didzis¹²,Perminov Dmitry¹³,Tauckels Eriks¹,Lindenberga Ilze¹,Tutāne Anna¹²,Auce Agris³

Affiliation:

1. E. Gulbis Laboratory , 366 Brīvības Av ., Rīga , , Latvia

2. Rīga Stradiņš University , 16 Dzirciema Str ., , Latvia

3. University of Latvia , 19 Raiņa Blvd ., Rīga , , Latvia

Abstract

Abstract This study compared the reference intervals (RI) of B12 vitamin concentration in blood found in the literature with RIs extracted from data accumulated from a large number of patients by E. Gulbis Laboratory in Latvia. This paper investigated and demonstrated the possibility of using large amounts of random patient data to establish the RI for clinical laboratory tests. The blood level of B12 vitamin was selected as the model system for this study. The study used blind data for B12 blood level measurements from 132 379 patients accumulated in E. Gulbis Laboratory over a period of 15 years. In order to establish the reference intervals, the frequency distribution of log transformed B12 values was fit to a Gaussian distribution. The established B12 reference interval of 196 pg/ml and 942 pg/ml was found to be in good agreement with RIs reported elsewhere.

Publisher

Walter de Gruyter GmbH

Link

https://www.sciendo.com/pdf/10.2478/prolas-2022-0050

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