Difference in Markers of Microbial Translocation and Cell Apoptosis in HIV Monoinfected and HIV/HCV Coinfected Patients-Reference-Cited by-同舟云学术

Difference in Markers of Microbial Translocation and Cell Apoptosis in HIV Monoinfected and HIV/HCV Coinfected Patients

Published:2019-07-12 Issue:4 Volume:73 Page:304-311
ISSN:1407-009X
Container-title:Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.
language:en
Short-container-title:

Author:

Madelāne Monta¹²,Krūmiņa Angelika¹,Sīmanis Raimonds¹,Šķenders Ģirts²³,Ivanovs Andrejs¹,Stūre Gunta¹²,Vīksna Ludmila¹²

Affiliation:

1. Department of Infectology and Dermatology , Rīga Stradiņš University , 3 Linezera Str., Rīga , LV- 1006 , Latvia

2. Rīga East University Hospital , 2 Hipokrāta Str., Rīga , LV- 1038 , Latvia

3. Institute of Clinical and Preventive Medicine , University of Latvia , 19 Raiņa blvd., Rīga , LV- 1586 , Latvia

Abstract

Abstract Immune activation in human immunodeficiency virus (HIV) infection is driven by microbial translocation and in HIV patients is one of the contributors to faster progression of liver disease along with increased cell apoptosis. The aim of the study was to compare microbial translocation and apoptosis markers in HIV monoinfected and HIV/hepatitis C virus (HCV) coinfected patients, depending on HIV immune status and antiretroviral treatment (ART). We analysed data for 78 HIV monoinfected and 105 HIV/HCV coinfected patients from the Rīga East University Hospital. Lipopolysaccharide (LPS), endotoxin core antibodies (EndoCAb), cytokeratin 18 (CK18) and cyto-chrome c (Cyt-c) levels were measured. No significant difference in LPS, EndoCAb, Cyt-c levels between HIV and HIV/HCV patients was found. The CK18 level was higher in the HIV/HCV group. Correlation between CD4+ cell count and EndoCAb antibodies was found in HCV positive patients. There was a significant effect of ART on markers for EndoCAb IgA and EndoCAb IgM antibodies in the HIV monoinfected group. Correlation between CD4+ cell count and EndoCAb antibodies and LPS was found in HIV/HCV patients on ART. Coinfection with HCV can lead to more pronounced response in EndoCAb antibody production and higher levels of cell apoptosis markers, despite similar LPS levels. ART has a positive effect on immune activation.

Publisher

Walter de Gruyter GmbH

Subject

Multidisciplinary

Link

https://www.sciendo.com/pdf/10.2478/prolas-2019-0048

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