The Level of Cytokeratin 18 in Patients with HIV and Viral Hepatitis C Co-Infection in Latvia-Reference-Cited by-同舟云学术

The Level of Cytokeratin 18 in Patients with HIV and Viral Hepatitis C Co-Infection in Latvia

Published:2020-04-01 Issue:2 Volume:74 Page:94-99
ISSN:2255-890X
Container-title:Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.
language:en
Short-container-title:

Author:

Koļesova Oksana¹²,Madelāne Monta¹,Ekšteina Ilze¹,Koļesovs Aleksandrs¹³,Krūmiņa Angelika¹,Vīksna Ludmila¹

Affiliation:

1. Faculty of Medicine , Rīga Stradiņš University , 3 Linezera Str., Rīga , LV- 1006 , Latvia

2. Institute of Microbiology and Virology , Rīga Stradiņš University , 5 Rātsupītes Str., Rīga , LV- 1067 , Latvia

3. Faculty of Education, Psychology and Art , University of Latvia , 1 Imantas 7 th Line, Rīga , Latvia

Abstract

Abstract Cytokeratin 18 (CK18) is a specific marker of hepatocellular apoptosis, which is a useful noninvasive indicator of liver fibrosis in the HIV/HCV group. However, data on the CK18 level in serum are limited for this group. This study demonstrated CK18 levels in serum in HIV/HCV co-infected and HIV mono-infected patients; investigated the association of CK18 levels with other non-invasive markers of liver fibrosis; and presents CK18 dynamics in a four-month-long period. The sample included 273 patients with HIV infection (128 of them were with HIV/HCV co-infection) aged from 23 to 65 (35% females). Levels of hyaluronic acid, CK18, ALT, and AST were determined in serum, and the FIB4 index was calculated. All markers had higher levels in the HIV/HCV group than in the HIV mono-infection group. The HIV/HCV group demonstrated coherent correlations among the markers and their associations with the level of CK18 than the HIV mono-infection group. During the four-month-long period, the CK18 level in serum showed no significant changes.

Publisher

Walter de Gruyter GmbH

Link

https://www.sciendo.com/pdf/10.2478/prolas-2020-0015

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