Author:
Nekulova Marta,Holcakova Jitka,Coates Philip,Vojtesek Borivoj
Abstract
AbstractThe transcription factor p63 has important functions in tumorigenesis, epidermal differentiation and stem cell self-renewal. The TP63 gene encodes multiple protein isoforms that have different or even antagonistic roles in these processes. The balance of p63 isoforms, together with the presence or absence of the other p53 family members, p73 and p53, has a striking biological impact. There is increasing evidence that interactions between p53-family members, whether cooperative or antagonistic, are involved in various cell processes. This review summarizes the current understanding of the role of p63 in tumorigenesis, metastasis, cell migration and senescence. In particular, recent data indicate important roles in adult stem cell and cancer stem cell regulation and in the response of cancer cells to therapy.
Subject
Cell Biology,Molecular Biology,Biochemistry
Reference176 articles.
1. A skin microRNA promotes differentiation by repressing stemness;Yi;Nature,2008
2. Downregulation of TAp and unaffected levels of beta distinguishes oral wounds from SCCHN;Thurfjell;Cell Cycle,2006
3. The human oncoprotein increases the transcriptional activity and the protein level of the homolog;Calabro;Biol Chem,2002
4. Medulloblastoma growth inhibition by hedgehog pathway blockade;Berman;Science,2002
5. Differential expression of isoforms in normal tissues and neoplastic cells;Nylander;Pathol,2002
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