A review on the epigenetics modifications to nanomaterials in humans and animals: Novel epigenetic regulator-Reference-Cited by-同舟云学术

A review on the epigenetics modifications to nanomaterials in humans and animals: Novel epigenetic regulator

Published:2023-07-01 Issue:3 Volume:23 Page:615-628
ISSN:2300-8733
Container-title:Annals of Animal Science
language:en
Short-container-title:

Author:

Aldal’in Hammad K.¹,Radhi Khadija S.²,Alazragi Reem³,Abdelnour Sameh⁴,Abukhalil Mohammad H.⁵⁶,Askar Ahmed M.⁷,Khalifa Norhan E.⁸,Noreldin Ahmed E.⁹,Althunibat Osama Y.¹⁰,Arif Muhammad¹¹,Abd El-Hack Mohamed E.¹²

Affiliation:

1. 1 Department of Medical Support , Al-Balqa Applied University, Al-Karak University College , Al-Karak , Jordan

2. 2 Department of Food Science and Nutrition , College of Science, Taif University , P.O. Box 11099, Taif 21944 , Saudi Arabia

3. 3 Department of Biochemistry , Faculty of Science, University of Jeddah , Jeddah , Kingdom of Saudi Arabia

4. 4 Animal Production Department, Faculty of Agriculture , Zagazig University , Zagazig , Egypt

5. 5 Department of Medical Analysis, Princess Aisha Bint Al-Hussein College of Nursing and Health Sciences , Al-Hussein Bin Talal University , Ma’an , Jordan

6. 6 Department of Biology , College of Science, Al-Hussein Bin Talal University , Ma’an , Jordan

7. 7 Faculty of Veterinary Medicine , Damanhour University , Damanhour , , Egypt

8. 8 Department of Physiology, Faculty of Veterinary Medicine , Fuka, Matrouh University , Matrouh , , Egypt

9. 9 Histology and Cytology Department, Faculty of Veterinary Medicine , Damanhour University , Damanhour , , Egypt

10. 10 Department of Medical Analysis, Princess Aisha Bint Al-Hussein College of Nursing and Health Sciences , Al-Hussein Bin Talal University , Ma’an , Jordan

11. 11 Department of Animal Sciences, College of Agriculture , University of Sargodha , Sargodha , Punjab , Pakistan

12. 12 Poultry Department, Faculty of Agriculture , Zagazig University , Zagazig , Egypt

Abstract

Abstract In the nanotechnology era, nanotechnology applications have been intensifying their prospects to embrace all the vigorous sectors persuading human health and animal. The safety and concerns regarding the widespread use of engineered nanomaterials (NMs) and their potential effect on human health still require further clarification. Literature elucidated that NMs exhibited significant adverse effects on various molecular and cellular alterations. Epigenetics is a complex process resulting in the interactions between an organism’s environment and genome. The epigenetic modifications, including histone modification and DNA methylation, chromatin structure and DNA accessibility alteration, regulate gene expression patterns. Disturbances of epigenetic markers induced by NMs might promote the sensitivity of humans and animals to several diseases. Also, this paper focuses on the epigenetic regulators of some dietary nutrients that have been confirmed to stimulate the epigenome and, more exactly, DNA histone modifications and non-histone proteins modulation by acetylation, and phosphorylation inhibition, which counteracts oxidative stress generations. The present review epitomizes the recent evidence of the potential effects of NMs on histone modifications, in addition to in vivo and in vitro cytosine DNA methylation and its toxicity. Furthermore, the part of epigenetic fluctuations as possible translational biomarkers for uncovering untoward properties of NMs is deliberated.

Publisher

Walter de Gruyter GmbH

Link

https://www.sciendo.com/pdf/10.2478/aoas-2023-0089

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