Bioavailability of 99mTc-paclitaxel-glucuronide (99mTc-PAC-G)-Reference-Cited by-同舟云学术

Bioavailability of 99mTc-paclitaxel-glucuronide (99mTc-PAC-G)

Published:2011-02-07 Issue:5 Volume:99 Page:301-306
ISSN:0033-8230
Container-title:Radiochimica Acta
language:en
Short-container-title:

Author:

Biber Muftuler Fazilet Zumrut,Demir Ilknur¹,Ünak P.²,Ichedef Cigdem³,Yurt Kilcar Ayfer²

Affiliation:

1. Ege University, Department of Nuclear Applications, Institute of Nuclear Sciences, 35100 Bornova, Izmir, Türkei

2. Ege University, Institute of Nuclear Sciences, 35100 Bornova, Izmir, Türkei

3. Ege University, Institute of Nuclear Sciences, Izmir, Türkei

Abstract

Abstract An antitumor agent paclitaxel (PAC) has been proved to be efficient in the treatment of breast and ovarian cancer. Glucuronic acid-derived paclitaxel compound [paclitaxel-glucuronide (PAC-G)] was enzymatically synthesized using microsome preparate separated from rat livers. The biodistribution mechanism of PAC-G in healthy female Albino Wistar rats has been investigated. The expected structure is confirmed according to LC/MS results, and the possible attachment is to C2-hydroxyl group. PAC-G was labeled with 99mTc and the radiochemical yield of radiolabeled compound (99mTc-PAC-G) was 98.0±02.74 (n=9). The range of the breast/blood and breast/muscle ratios is approximately between 3 and 35 in 240ߙmin. All these experimental studies indicate that 99mTc-PAC-G may potentially be used in breast tissue as an imaging agent.

Publisher

Walter de Gruyter GmbH

Subject

Physical and Theoretical Chemistry

Link

https://www.degruyter.com/document/doi/10.1524/ract.2011.1827/pdf

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