Quantitation in Neuropathology

Abstract

Qualitative neuropathologic evaluations are appropriate for initial screening of compounds for neurotoxicity. In the future, advances in tissue preparation and computer technology will make quantitative evaluation of some nervous tissue structures more routine. These evaluations will be used as part of tier II studies to determine dose-responses or no-effect levels. Quantitative methods can enable small but significant differences to be detected, and the data can be subjected to statistical analysis.