Final Report of the Safety Assessment of Polyamino Sugar Condensate

Abstract

Polyamino Sugar Condensate (PSC) is the product of a condensation reaction between amino acids and sugars. It appears in over 100 cosmetic preparations at concentrations up to 1%. PSC has an acute oral toxicity greater than 5 g/kg in rats. In tests on rabbits, undiluted PSC was not a primary irritant and produced only mild irritation in some animals. Subacute skin irritation was not observed in rabbits when PSC (undiluted) was applied. Human safety data indicate that PSC is nonsensitizing and, at worst, a mild irritant. PSC is also nonphototoxic. On the basis of the available animal data and limited human experience, it is concluded that Polyamino Sugar Condensate is safe for topical application to humans.