Using human recombinant UDP-glucuronosyltransferase isoforms and a relative activity factor approach to model total body clearance of laropiprant (MK-0524) in humans-Reference-Cited by-同舟云学术

Using human recombinant UDP-glucuronosyltransferase isoforms and a relative activity factor approach to model total body clearance of laropiprant (MK-0524) in humans

Published:2013-05-03 Issue:12 Volume:43 Page:1027-1036
ISSN:0049-8254
Container-title:Xenobiotica
language:en
Short-container-title:Xenobiotica

Author:

Gibson Christopher R.,Lu Ping,Maciolek Cheri,Wudarski Christen,Barter Zoe,Rowland-Yeo Karen,Stroh Mark,Lai Eseng,Nicoll-Griffith Deborah A.

Publisher

Informa UK Limited

Subject

Health, Toxicology and Mutagenesis,Pharmacology,Toxicology,Biochemistry,General Medicine

Link

http://www.tandfonline.com/doi/pdf/10.3109/00498254.2013.791761

Reference32 articles.

1. Prediction of total propofol clearance based on enzyme activities in microsomes from human kidney and liver

2. Scaling Factors for the Extrapolation of In Vivo Metabolic Drug Clearance From In Vitro Data: Reaching a Consensus on Values of Human Micro-somal Protein and Hepatocellularity Per Gram of Liver

3. The pharmacokinetics and disposition of MK-0524, a Prostaglandin D2receptor 1 antagonist, in rats, dogs and monkeys

4. Utility of Intersystem Extrapolation Factors in Early Reaction Phenotyping and the Quantitative Extrapolation of Human Liver Microsomal Intrinsic Clearance Using Recombinant Cytochromes P450

5. The use of heterologously expressed drug metabolizing enzymes— state of the art and prospects for the future

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