Estimation of fraction of drug metabolism by a single UDP‐glucuronosyl transferase enzyme using relative expression factor-Reference-Cited by-同舟云学术

Estimation of fraction of drug metabolism by a single UDP‐glucuronosyl transferase enzyme using relative expression factor

Published:2022-09-30 Issue:5 Volume:43 Page:213-217
ISSN:0142-2782
Container-title:Biopharmaceutics & Drug Disposition
language:en
Short-container-title:Biopharm & Drug Disp

Author:

Honda Tomoyo¹^ORCID,Obuchi Wataru¹,Nishiya Yumi¹,Shibayama Takahiro¹,Watanabe Kengo¹,Watanabe Nobuaki¹

Affiliation:

1. Drug Metabolism & Pharmacokinetics Research Laboratory R&D Division Daiichi Sankyo Company, Ltd Shinagawa‐ku Japan

Publisher

Wiley

Subject

Pharmacology (medical),Pharmaceutical Science,Pharmacology,General Medicine

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/bdd.2330

Reference17 articles.

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4. Targeted Precise Quantification of 12 Human Recombinant Uridine-Diphosphate Glucuronosyl Transferase 1A and 2B Isoforms Using Nano-Ultra-High-Performance Liquid Chromatography/Tandem Mass Spectrometry with Selected Reaction Monitoring

5. Using human recombinant UDP-glucuronosyltransferase isoforms and a relative activity factor approach to model total body clearance of laropiprant (MK-0524) in humans