Pharmacokinetics and first-pass elimination of metoprolol in rats: contribution of intestinal first-pass extraction to low bioavailability of metoprolol-Reference-Cited by-同舟云学术

Pharmacokinetics and first-pass elimination of metoprolol in rats: contribution of intestinal first-pass extraction to low bioavailability of metoprolol

Published:2010-12-03 Issue:3 Volume:41 Page:243-251
ISSN:0049-8254
Container-title:Xenobiotica
language:en
Short-container-title:Xenobiotica

Author:

Yoon In-Soo,Choi Min-Koo,Kim Jung Sun,Shim Chang-Koo,Chung Suk-Jae,Kim Dae-Duk

Publisher

Informa UK Limited

Subject

Health, Toxicology and Mutagenesis,Pharmacology,Toxicology,Biochemistry,General Medicine

Link

http://www.tandfonline.com/doi/pdf/10.3109/00498254.2010.538090

Reference25 articles.

1. Influence of quinidine, cimetidine, and ketoconazole on the enantioselective pharmacokinetics and metabolism of metoprolol in rats

2. Pharmacokinetic studies of metoprolol-(3H) in the rat and the dog

3. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

4. Why is it Challenging to Predict Intestinal Drug Absorption and Oral Bioavailability in Human Using Rat Model

5. Influence of Chronic Renal Failure on Stereoselective Metoprolol Metabolism in Hypertensive Patients

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