Why is it Challenging to Predict Intestinal Drug Absorption and Oral Bioavailability in Human Using Rat Model-Reference-Cited by-同舟云学术

Why is it Challenging to Predict Intestinal Drug Absorption and Oral Bioavailability in Human Using Rat Model

Published:2006-07-14 Issue:8 Volume:23 Page:1675-1686
ISSN:0724-8741
Container-title:Pharmaceutical Research
language:en
Short-container-title:Pharm Res

Author:

Cao Xianhua,Gibbs Seth T.,Fang Lanyan,Miller Heather A.,Landowski Christopher P.,Shin Ho-Chul,Lennernas Hans,Zhong Yanqiang,Amidon Gordon L.,Yu Lawrence X.,Sun Duxin

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Organic Chemistry,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biotechnology

Link

http://link.springer.com/content/pdf/10.1007/s11095-006-9041-2.pdf

Reference83 articles.

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2. C. L. Cummins, W. Jacobsen, and L. Z. Benet. Unmasking the dynamic interplay between intestinal P-glycoprotein and CYP3A4. J. Pharmacol. Exp. Ther. 300:1036–1045 (2002).

3. G. L. Amidon, H. Lennernas, V. P.Shah, and J. R. Crison. A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability. Pharm. Res. 12:413–420 (1995).

4. H. Lennernas. Human intestinal permeability. J. Pharm. Sci. 87:403–410 (1998).

5. W. L. Chiou. The validation of the intestinal permeability approach to predict oral fraction of dose absorbed in humans and rats. Biopharm. Drug Dispos. 16:71–75 (1995).

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