Comparison of intrinsic clearances in human liver microsomes and suspended hepatocytes from the same donor livers: clearance-dependent relationship and implications for prediction ofin vivoclearance-Reference-Cited by-同舟云学术

Comparison of intrinsic clearances in human liver microsomes and suspended hepatocytes from the same donor livers: clearance-dependent relationship and implications for prediction ofin vivoclearance

Published:2010-11-09 Issue:2 Volume:41 Page:124-136
ISSN:0049-8254
Container-title:Xenobiotica
language:en
Short-container-title:Xenobiotica

Author:

Foster Joanne A.,Houston J. Brian,Hallifax David

Publisher

Informa UK Limited

Subject

Health, Toxicology and Mutagenesis,Pharmacology,Toxicology,Biochemistry,General Medicine

Link

http://www.tandfonline.com/doi/pdf/10.3109/00498254.2010.530700

Reference24 articles.

1. Kinetic determinants of hepatic clearance: Plasma protein binding and hepatic uptake

2. Scaling Factors for the Extrapolation of In Vivo Metabolic Drug Clearance From In Vitro Data: Reaching a Consensus on Values of Human Micro-somal Protein and Hepatocellularity Per Gram of Liver

3. Evaluation of Cryopreserved Human Hepatocytes as an Alternative in Vitro System to Microsomes for the Prediction of Metabolic Clearance

4. Biotransformation of alprazolam by members of the human cytochrome P4503A subfamily

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