Synthesis and biological evaluation of biguanide and dihydrotriazine derivatives as potential inhibitors of dihydrofolate reductase of opportunistic microorganisms
Author:
Affiliation:
1. Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Nathalal Parekh Marg, Matunga, Mumbai, India
2. Department of Pharmacology and Toxicology, School of Medicine, Indiana University, Indianapolis, IN, USA
Publisher
Informa UK Limited
Subject
Drug Discovery,Pharmacology,General Medicine
Link
https://www.tandfonline.com/doi/pdf/10.3109/14756360903179443
Reference25 articles.
1. Towards Species-specific Antifolates
2. Dihydrofolate Reductase as a Target for Chemotherapy in Parasites
3. Novel non-classical C9-methyl-5-substituted-2,4-diaminopyrrolo[2,3-d]pyrimidines as potential inhibitors of dihydrofolate reductase and as anti-opportunistic agents
4. N9-Substituted 2,4-Diaminoquinazolines: Synthesis and Biological Evaluation of Lipophilic Inhibitors of Pneumocystis carinii and Toxoplasma gondii Dihydrofolate Reductase
5. Highly Efficient Ligands for Dihydrofolate Reductase from Cryptosporidium hominis and Toxoplasma gondii Inspired by Structural Analysis
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