Highly Efficient Ligands for Dihydrofolate Reductase from Cryptosporidium hominis and Toxoplasma gondii Inspired by Structural Analysis-Reference-Cited by-同舟云学术

Highly Efficient Ligands for Dihydrofolate Reductase from Cryptosporidium hominis and Toxoplasma gondii Inspired by Structural Analysis

Published:2007-02-02 Issue:5 Volume:50 Page:940-950
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Pelphrey Phillip M.¹,Popov Veljko M.¹,Joska Tammy M.¹,Beierlein Jennifer M.¹,Bolstad Erin S. D.¹,Fillingham Yale A.¹,Wright Dennis L.¹,Anderson Amy C.¹

Affiliation:

1. Department of Chemistry, Dartmouth College, Hanover, New Hampshire 03755, Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755, Department of Chemistry, University of Connecticut, Storrs, Connecticut 06269, and Department of Pharmaceutical Sciences, University of Connecticut, Storrs, Connecticut 06269

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm061027h

Reference34 articles.

1. Targeting DHFR in parasitic protozoa

2. Analysis of complexes of inhibitors with Cryptosporidium hominis DHFR leads to a new trimethoprim derivative

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