Affiliation:
1. University of Oslo
2. Institute of Scientific Computing
3. TU Dresden
4. Center for Systems Biology Dresden
5. Cluster of Excellence
Abstract
T1 transitions, also called cell intercalations, are important sources of fluidization of epithelial cell monolayers. We use a multiphase field model to quantify this tissue fluidization in terms of the relative dispersion of cells and characterize the T1 flow profile. We show that the ensemble-averaged flow profile of a T1 transition has a saddle-point pattern accompanied by a localized burst in cell speed. Although the temporal evolution of the relative dispersion of cells depends on specific model details, the different dispersion curves collapse robustly onto a linear function of the number of T1 transitions, implying an important connection between T1 transitions and mixing in dense systems.
Published by the American Physical Society
2024
Funder
Deutsche Forschungsgemeinschaft
Publisher
American Physical Society (APS)
Cited by
1 articles.
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