Affiliation:
1. European Molecular Biology Laboratory
2. Politecnico di Torino
3. Hubrecht Institute
4. Kyoto University
5. INFN
6. Heidelberg University
Abstract
Cellular Potts models are broadly applied across developmental biology and cancer research. We overcome limitations of the traditional approach, which reinterprets a modified Metropolis sampling as dynamics, by introducing a physical timescale through Poissonian kinetics and by applying principles of stochastic thermodynamics to separate thermal and relaxation effects from athermal noise and nonconservative forces. Our method accurately describes cell-sorting dynamics in mouse-embryo development and identifies the distinct contributions of nonequilibrium processes, e.g., cell growth and active fluctuations.
Published by the American Physical Society
2024
Funder
H2020 European Research Council
Japan Society for the Promotion of Science
Gruppo Nazionale per la Fisica Matematica
Ministero dell’Università e della Ricerca
Publisher
American Physical Society (APS)
Cited by
2 articles.
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