Author:
Lioznov D. A.,Kharit S. M.,Erofeeva M. K.,Zubkova T. G.,Gorchakova O. V.,Nikolaenko S. L.
Abstract
In this multicenter double blind randomized clinical study with parallel groups conducted with 612 healthy volunteers, domestic influenza quadrivalent inactivated subunit vaccine Grippol® Quadrivalent safety, tolerability and immunogenicity was evaluated in comparison with seasonal trivalent vaccines, It was demonstrated that quadrivalent influenza vaccine Grippol® Quadrivalent possesses good tolerability, low reactogenicity, and has favorable safety profile similar to that for trivalent comparators. Besides, it was proven that quadrivalent influenza vaccine Grippol® Quadrivalent has same immunogenicity for three conventional strains and significantly exceeds trivalent comparators for missed influenza B strain.
Subject
Infectious Diseases,Public Health, Environmental and Occupational Health,Epidemiology
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