Fragment synthesis of A. baumannii ATCC 17961 O-antigen

Abstract

Acinetobacter baumannii can cause many diseases including septiceamia, pneumonia, meningitis, soft tissue and urinary tract infections. Herein, we described the synthesis of one trisaccharide and two tetrasaccharide fragments derived from A. baumannii ATCC 17961 O-antigen, which can be used for screening novel glyco-epitope and developing synthetic carbohydrate-based vaccine against A. baumannii infection. The overall yields for the synthesis of trisaccharide 1, tetrasaccharide 2 and tetrasaccharide 3 are 26.8% (8 steps), 21.6% (9 steps) and 24.5% (6 steps), respectively.