Author:
Nobuta Tomoya,Morishita Honoka,Suto Yutaka,Yamagiwa Noriyuki
Abstract
AbstractAmidation of amino acids using dichloro(methyl)(3,3,3-trifluoropropyl)silane (MTFPSCl2) and imidazole is described. MTFPSCl2 activates the carboxy group and protects the α-amino group of amino acids. The amidation proceeded with 19 amino acids and 19 amines, including α-branched amines and anilines; the corresponding amino acid amides were synthesized in good-to-high yields (up to 96%) with low-to-no racemization.
Cited by
4 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献