Recent Advances on Benzofuranones: Synthesis and Transformation via C–H Functionalization

Abstract

AbstractThe benzofuranone structure is important in many fields, such as natural products, pharmaceuticals, building blocks, antioxidants, and dyes. The efficient synthesis and transformation of benzofuranones have attracted great attention in organic synthesis. They can be synthesized by the Friedel–Crafts reaction and intramolecular dehydration ring-closing and transition-metal-catalyzed reactions, among others. Their direct utilization in the preparation of other functional molecules further enhance their application. Due to their low pK a value and easy enolization, the transformation of benzofuranones via C(3)–H bond functionalization has been a hot issue since 2010. Herein, we highlight advances in the synthesis of benzofuranones and their transformation via C–H functionalization. Other transformations related to benzofuranones are also discussed.1 Introduction2 Synthesis of Benzofuranones3 C–H Functionalization of Benzofuranones4 Other Types of Reactions of Benzofuranones5 Conclusion and Outlook