Hopeahainol A attenuates memory deficits by targeting β-amyloid in APP/PS1 transgenic mice

Author:

Zhu Xiaolei,Ye Lan1,Ge Huiming2,Chen Ling3,Jiang Nan,Qian Lai1,Li Lingling1,Liu Rong1,Ji Shen4,Zhang Su4,Jin Jiali1,Guan Dening1,Fang Wei2,Tan Renxiang2,Xu Yun

Affiliation:

1. Department of Neurology; Affiliated Drum Tower Hospital of Nanjing University Medical School; Nanjing; China

2. Institute of Functional Biomolecules; State Key Laboratory of Pharmaceutical Biotechnology; Nanjing University; Nanjing; China

3. Department of Physiology; Nanjing Medical University; Nanjing; China

4. Department of Traditional Chinese Medicine; Shanghai Institute of Food & Drug Controls; Shanghai; China

Publisher

Wiley

Subject

Cell Biology,Ageing

Reference23 articles.

1. Acetylcholinesterase promotes the aggregation of amyloid-beta-peptide fragments by forming a complex with the growing fibrils;Alvarez;J. Mol. Biol.,1997

2. Abeta toxicity in Alzheimer's disease;Cavallucci;Mol. Neurobiol.,2012

3. Modulatory metaplasticity induced by pregnenolone sulfate in the rat hippocampus: a leftward shift in LTP/LTD-frequency curve;Chen;Hippocampus,2010

4. Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function;Cleary;Nat. Neurosci.,2005

5. Hopeahainol A: an acetylcholinesterase inhibitor from Hopea hainanensis;Ge;Chemistry,2008

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