Author:
Lee Sang-Hyeup,Lee Ji-Hoon
Abstract
AbstractDimethylalkynylaluminum reagents derived from terminal alkynes and trimethylaluminum underwent addition to various N-activated α-amido sulfones to produce the corresponding alkynylamines in moderate to excellent yields. The optimized protocol avoids the preparation and isolation of relatively unstable N-activated imines that are generated in situ from their corresponding, stable, N-activated α-amido sulfones. This methodology provides access to a wide range of alkynylamines containing N-carbamoyl, -acyl, and -sulfonyl moieties.
Funder
National Research Foundation of Korea
Subject
Organic Chemistry,Catalysis
Cited by
1 articles.
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