Affiliation:
1. Department of Ophthalmology, The Second Affiliated Hospital of Soochow
University, Suzhou, China
2. Department of Ophthalmology, The First Affiliated Hospital of Soochow
University, Suzhou, China
Abstract
AbstractDiabetes confers an increased risk of microvascular complications, including
retinopathy. However, whether prediabetes is also related to retinopathy has not
been comprehensively examined. We performed a meta-analysis to evaluate the
relationship between prediabetes and retinopathy. This meta-analysis included
relevant observational studies from Medline, Embase, and Web of Science
databases. A random-effect model after incorporation of the intra-study
heterogeneity was selected to pool the results. Subgroup analyses were applied
to evaluate the influences of study characteristics on relationship. Nine
cross-sectional studies including 14 751 community dwelling adult participants
were included; 3847 (26.1%) of them were prediabetic. Results showed
that prediabetes was associated with a higher prevalence of retinopathy compared
to normoglycemia [odds ratio (OR): 1.55, 95% confidence interval (CI):
1.10–2.20, p=0.01, I2=34%].
Sensitivity analysis by excluding one study at a time showed consistent result
(OR: 1.35 to 1.73, p all<0.05). Subgroup analysis showed study
characteristics such as definition of prediabetes, country of study, sample
size, mean age of participants, or univariate or multivariate analyses may not
significantly affect the association (p for subgroup difference
all>0.05). Current evidence suggests that patients with prediabetes may
be associated with higher prevalence of retinopathy as compared to those with
normoglycemia. Although prospective cohort studies are needed to validate these
findings, results of our meta-analysis highlighted the importance of early
prevention of retinopathy in patients with prediabetes.
Funder
National Natural Science Foundation of China
Suzhou Science and Technology Fund of China
Subject
Biochemistry, medical,Clinical Biochemistry,Endocrinology,Biochemistry,General Medicine,Endocrinology, Diabetes and Metabolism