Synthesis of Imidazole and Histidine-Derived Cross-Linkers as Analogues of GOLD and Desmosine-Reference-Cited by-同舟云学术

Synthesis of Imidazole and Histidine-Derived Cross-Linkers as Analogues of GOLD and Desmosine

Published:2021-02-22 Issue:13 Volume:53 Page:2260-2268
ISSN:0039-7881
Container-title:Synthesis
language:en
Short-container-title:Synthesis

Author:

Bilitewski Ursula¹,Laschat Sabine²^ORCID,Schädel Nicole²,Icik Esra²,Martini Maike²,Altevogt Luca²¹,Ramming Isabell¹,Greulich Andreas²,Baro Angelika²

Affiliation:

1. AG Compound Profiling and Screening, Helmholtz Zentrum für Infektionsforschung

2. Institut für Organische Chemie, Universität Stuttgart

Abstract

AbstractAmino acid derivatives with a central cationic heterocyclic core (e.g., imidazolium) are biologically relevant cross-linkers of proteins and advanced glycation end (AGE) products. Here, imidazolium-containing cross-linkers were synthesized from imidazole or histidine by N-alkylation employing aspartate- and glutamate-derived mesylates as key step. Biological investigations were carried out to probe the biocompatibility of these compounds.

Funder

Ministerium für Wissenschaft, Forschung und Kunst Baden-Württemberg

Carl-Zeiss-Stiftung

Publisher

Georg Thieme Verlag KG

Subject

Organic Chemistry,Catalysis

Link

http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0040-1706144.pdf

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