Suzuki–Miyaura Coupling Reactions of Fluorohalobenzenes

Abstract

AbstractOrganofluorine compounds have gained interest in the fields of pharmaceuticals, agrochemicals, diagnostics, materials, and catalysis. Suzuki–Miyaura coupling reactions of fluorinated arenes made a tremendous impact in chemical and biological research and made organofluorinated molecules more readily available. This review gives a brief summary of Suzuki–Miyaura coupling reactions of fluorinated benzene derivatives. In this context, various aspects, such as regio­selectivity, efficiency, and applications, are discussed.1 Introduction2 Organofluorine Compounds3 Suzuki–Miyaura Reactions of Fluorohalobenzenes3.1 Fluorophthalates3.2 Reactions of Pentafluorohalobenzenes3.3 Tetrafluorohalobenzenes3.4 Trifluorohalobenzenes3.5 Difluorohalobenzenes3.6 Monofluorohalobenzenes3.7 Halo(trifluoromethyl)benzenes3.8 Trifluoromethyl Pyridines4 S Summary