Synthesis of 6-Chloro-5-(trifluoroacetyl)pyridine-3-carbonitrile: A Novel, Versatile Intermediate for the Synthesis of Trifluoromethylated Azaindazole Derivatives-Reference-Cited by-同舟云学术

Synthesis of 6-Chloro-5-(trifluoroacetyl)pyridine-3-carbonitrile: A Novel, Versatile Intermediate for the Synthesis of Trifluoromethylated Azaindazole Derivatives

Published:2019-05-02 Issue:09 Volume:30 Page:1057-1060
ISSN:0936-5214
Container-title:Synlett
language:en
Short-container-title:Synlett

Author:

Channapur Manjunath¹,Hall Roger²,Kessabi Jilali²,Montgomery Mark³,Shyadligeri Ashok¹

Affiliation:

1. Syngenta Biosciences Private Limited, Santa Monica Works

2. Syngenta Crop Protection AG

3. Syngenta Jealott’s Hill International Research Centre

Abstract

A synthesis of 6-chloro-5-(trifluoroacetyl)pyridine-3-carbonitrile, a versatile building block for the synthesis of trifluoromethylated N-heterocycles, is described. The reactions of 6-chloro-5-(trifluoroacetyl)pyridine-3-carbonitrile with 1,2- and 1,3-bisnucleophiles were investigated.

Publisher

Georg Thieme Verlag KG

Subject

Organic Chemistry

Link

http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0037-1611815.pdf

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