Synthesis of 2‐Chloro‐6‐(trifluoromethyl)pyridine‐3,5‐dicarbonitrile: A Versatile Building Block for the Synthesis of Substituted Trifluoro Methyl Pyridine Derivatives

Abstract

AbstractA simple and highly efficient (concise 3‐step) synthesis of 2‐chloro–6‐(trifluoromethyl)pyridine‐3,5‐dicarbonitrile has been developed from readily available starting materials. Furthermore, the selective reactivity of this tetra‐ substituted pyridine with different carbon, sulfur, nitrogen and oxygen nucleophiles offers great scope for the synthesis of novel highly substituted pyridine derivatives in decent to good yields.