Synthesis and Antiproliferative Properties of Bifunctional Allocolchicine Derivatives-Reference-Cited by-同舟云学术

Synthesis and Antiproliferative Properties of Bifunctional Allocolchicine Derivatives

Published:2018-05-28 Issue:14 Volume:50 Page:2753-2760
ISSN:0039-7881
Container-title:Synthesis
language:en
Short-container-title:Synthesis

Author:

Fedorov Alexey¹,Gracheva Iuliia¹,Svirshchevskaya Elena²,Faerman Vladimir¹,Beletskaya Irina³

Affiliation:

1. Department of Organic Chemistry, N.I. Lobachevsky State University of Nizhny Novgorod

2. Laboratory of Cell Interactions, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS

3. Department of Chemistry, M. V. Lomonosov Moscow State University

Abstract

Based on the natural antimitotic agent colchifoline as a lead structure, a series of novel bifunctional allocolchicine congeners were synthesized from commercial colchicine. The new derivatives maintain good cytotoxicity against T3M4, MiaPaCa-2, and PANC-1 cell lines. The presence of functional groups simplifies further modifications of the prepared structures and the design of novel colchicine-derived antitumor compounds with desired pharmacological properties.

Funder

Russian Science Foundation

Publisher

Georg Thieme Verlag KG

Subject

Organic Chemistry,Catalysis

Link

http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0037-1610146.pdf

Cited by 10 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. The chemistry of heterocycles in the 21st century;Russian Chemical Reviews;2024-07

2. Regioselective approach to colchiceine tropolone ring functionalization at C(9) and C(10) yielding new anticancer hybrid derivatives containing heterocyclic structural motifs;Journal of Enzyme Inhibition and Medicinal Chemistry;2022-01-24

3. B-nor-methylene Colchicinoid PT-100 Selectively Induces Apoptosis in Multidrug-Resistant Human Cancer Cells via an Intrinsic Pathway in a Caspase-Independent Manner;ACS Omega;2022-01-11

4. Synthesis of highly substituted fluorenones via metal-free TBHP-promoted oxidative cyclization of 2-(aminomethyl)biphenyls. Application to the total synthesis of nobilone;Beilstein Journal of Organic Chemistry;2021-11-02

5. In(ONf)3-catalyzed 7-membered carbon-ring-forming annulation of heteroarylindoles with α,β-unsaturated carbonyl compounds;Organic Chemistry Frontiers;2021