Author:
Nagalatha G.,Narala Siva,Narsaiah A.
Abstract
An efficient protecting-group-free synthesis of tumonoic acid A and its derivatives has been accomplished. The synthesis started from commercially available n-octanal and employs the magnesium chloride catalysed anti-aldol reaction under the Evans protocol as the key step. Ethyl tumonoate A is a new tumonoic acid derivative with anti-inflammatory activity and inhibitory activity towards calcium oscillations in neocortical neurons.
Subject
Organic Chemistry,Materials Science (miscellaneous),Biomaterials,Catalysis
Cited by
9 articles.
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