Affiliation:
1. Organic Synthesis Laboratory Fluoro-Agrochemicals Department CSIR-Indian Institute of Chemical Technology Hyderabad 500007 Telangana India
2. Academy of Scientific and Innovative Research (AcSIR) Ghaziabad 201002 India
Abstract
AbstractThe total synthesis of marine sponge products dysideolide A and B have been achieved in stereo controlled manner. The butenolide and pentenolide lactones are consisting of sensitive, α,β‐unsaturated cis‐olefin functional group and which was installed by Still‐Gennari olefination with ketone. The synthesis starts from D‐mannitol and D‐ribose respectively. Notable features of the synthesis are Z‐selective Still‐Gennari olefination, Pinnick oxidation and Shiina macrolactonization.