Total Synthesis of Natural Products Dysideolide A and B

Abstract

AbstractThe total synthesis of marine sponge products dysideolide A and B have been achieved in stereo controlled manner. The butenolide and pentenolide lactones are consisting of sensitive, α,β‐unsaturated cis‐olefin functional group and which was installed by Still‐Gennari olefination with ketone. The synthesis starts from D‐mannitol and D‐ribose respectively. Notable features of the synthesis are Z‐selective Still‐Gennari olefination, Pinnick oxidation and Shiina macrolactonization.