Synthesis of 2-Imidazolines via Palladium-Catalyzed Cyclization Reaction of 2,3-Allenyl Amines and Aryl Iodides

Author:

Liu Yue,Zhang Cheng,Liang Xiaoxia,Zeng Xianzhong,Lu Rongmei,Fang Zixuan,Wang Shaoyu,Liu Yanjun,Hu Jinxing1ORCID

Affiliation:

1. School of Pharmacy, Weifang Medical University

Abstract

An effective method for the synthesis of polysubstituted 2-imidazoline derivatives via palladium-catalyzed cyclization of 2,3-allenyl amines with aryl iodides is described. This pure domino process allows the formation of new carbon–carbon and carbon–nitrogen bonds in a single synthetic operation.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Shandong Province

Weifang University of Science and Technology

Publisher

Georg Thieme Verlag KG

Subject

Organic Chemistry,Catalysis

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