Author:
Deepthi Ani,Thomas Noble V.,Meenakshy C. B.,Leena Sruthi S.
Abstract
AbstractHighly regio- and stereoselective synthesis of dispiropyrrolo[2,1-a]isoquinoline-oxindoles have been developed by the one-pot three component reaction of isatins, 1,2,3,4-tetrahydroisoquinoline (THIQ), and a thiazolo[3,2-a]indole derivative. The reaction proceeds regioselectively through an exo-Re face approach of the in situ generated tetrahydroisoquinolium ylides towards the dipolarophile yielding the corresponding [3+2] cycloadducts in excellent yields and stereoselectivity.
Funder
University Grants Commission
University of Kerala
Subject
Organic Chemistry,Catalysis
Cited by
5 articles.
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