The Huisgen Reaction: Milestones of the 1,3‐Dipolar Cycloaddition

Author:

Breugst Martin1ORCID,Reissig Hans‐Ulrich2ORCID

Affiliation:

1. Department für Chemie Universität zu Köln Greinstrasse 4 50939 Köln Germany

2. Institut für Chemie und Biochemie Freie Universität Berlin Takustrasse 3 14195 Berlin Germany

Publisher

Wiley

Subject

General Chemistry,Catalysis

Reference253 articles.

1.  

2. Looking back Huisgen was not happy about the choice of the name because it may be misleading. The name 1 3-dipole may imply high dipole moments of these compounds which is not the case for many 1 3-dipoles.

3. In the first reviews (e.g. in ref. [33]) reactions of 1 3-dipoles without octet stabilization were included for instance those of keto carbenes. Later it was recognized that they are better regarded as 2π components in cycloadditions.

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