Synthesis of 1,3,4-Oxadiazoles by Iodine-Mediated Oxidative Cyclization of Methyl Ketones with 4-Phenylsemicarbazide-Reference-Cited by-同舟云学术

Synthesis of 1,3,4-Oxadiazoles by Iodine-Mediated Oxidative Cyclization of Methyl Ketones with 4-Phenylsemicarbazide

Published:2021-11-25 Issue:03 Volume:33 Page:269-272
ISSN:0936-5214
Container-title:Synlett
language:en
Short-container-title:Synlett

Author:

Leng Yuting¹^ORCID,Wu Yangjie¹^ORCID,Zhang Shanshan¹,Liu Chuang¹,Wu Xiaojun¹,Li Wen¹,Li He¹,Wang Shiwei²

Affiliation:

1. Green Catalysis Center, and College of Chemistry, Key Laboratory of Chemical Biology and Organic Chemistry of Henan Province, Zhengzhou University

2. School of Mechanics and Engineering Science, Zhengzhou University

Abstract

AbstractAn efficient one-pot method has been developed to access 5-amino-2-(het)aroyl-1,3,4-oxadiazoles through I2/DMSO-promoted oxidative cyclization of 4-phenylsemicarbazide with (het)aryl methyl ketones under mild conditions. This reaction proceeds smoothly with a wide range of methyl ketones containing various functional groups to give the corresponding products in moderate yields under mild conditions.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Henan Province

Publisher

Georg Thieme Verlag KG

Subject

Organic Chemistry

Link

http://www.thieme-connect.de/products/ejournals/pdf/10.1055/a-1707-0965.pdf

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