Affiliation:
1. College of Chemistry and Chemical Engineering, Yunnan Normal University
2. Key Laboratory for Chemical Biology of Fujian Province and College of Chemistry and Chemical Engineering, Xiamen University
3. State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
Abstract
AbstractThe [1,2]-Stevens rearrangement is a widely used transformation in synthetic organic chemistry. However, enantioselective versions are relatively limited and most of them rely on substrate-induced methodologies. In recent years, metal carbene chemistry has been extensively investigated, and the related asymmetric [1,2]-Stevens rearrangement has experienced rapid development by employing ylide intermediates generated from the reaction of metal carbenes with heteroatoms. This review summarizes recent advances in the asymmetric [1,2]-Stevens-type rearrangement via metal carbenes by presenting their product diversity, selectivity, and mechanistic rationale, which is organized based on the mode of chirality control.1 Introduction2 Substrate-Induced Asymmetric [1,2]-Stevens-Type Rearrangement3 Catalyst-Controlled Asymmetric [1,2]-Stevens-Type Rearrangement4 Conclusion and Outlook
Funder
National Natural Science Foundation of China
Yunnan Normal University
Applied Basic Research Projects of Yunnan Province
Subject
Organic Chemistry,Catalysis
Cited by
8 articles.
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