Selective Synthesis of Tetrahydro Oxepines by Cu‐Catalyzed Condensations of Diazomalonates and <i>gem</i>‐Dialkyl Vinyl Oxetanes-Reference-Cited by-同舟云学术

Selective Synthesis of Tetrahydro Oxepines by Cu‐Catalyzed Condensations of Diazomalonates and gem‐Dialkyl Vinyl Oxetanes

Published:2024-01-26 Issue:5 Volume:366 Page:1070-1077
ISSN:1615-4150
Container-title:Advanced Synthesis & Catalysis
language:en
Short-container-title:Adv Synth Catal

Author:

Montagnon Claire¹,Pertschi Romain¹,Besnard Céline²,Lacour Jérôme¹^ORCID

Affiliation:

1. Department of Organic Chemistry University of Geneva Quai Ernest Ansermet 30 1211 Geneva 4 Switzerland

2. Laboratory of Crystallography University of Geneva Quai Ernest Ansermet 24 1211 Geneva 4 Switzerland

Abstract

AbstractThanks to an unprecedented gem‐dialkyl substituent effect, an efficient synthesis of tetrahydro oxepine derivatives is achieved by ring expansion of vinyl oxetanes using acceptor(−acceptor) diazo reagents under Cu(II)‐catalysis. A large scope of 2‐vinyl oxetanes and either diazo mono or diester reagents give access to a series of functionalized oxepines.

Funder

Université de Genève

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

Publisher

Wiley

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/adsc.202301399

Reference119 articles.

2. Oxetanes in Drug Discovery Campaigns

3. From Oxiranes to Oligomers: Architectures of U.S. FDA Approved Pharmaceuticals Containing Oxygen Heterocycles

4. Oxetanes as Versatile Elements in Drug Discovery and Synthesis

Cited by 3 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Polycyclic Pyrazolidines by Tandem Diazomalonate Dipolar Cycloadditions and CpRu‐Catalyzed Carbene Additions;Chemistry – A European Journal;2024-07-11

2. A Copper-Catalyzed [2,3]-Stevens Rearrangement to Access Functionalized Tetrahydro Oxepines;Synfacts;2024-03-13

3. A copper-catalyzed annulation reaction of diazo esters with propargyl amines for the synthesis of 2,5-dihydropyrroles;Organic Chemistry Frontiers;2024