The Role of Kinetics as Key Determinant in Toxicity of Pyrrolizidine Alkaloids and Their N-Oxides
Author:
Affiliation:
1. Division of Toxicology, Wageningen University and Research, The Netherlands
2. Department of Food Science and Human Nutrition, College of Agriculture and Veterinary Medicine, Qassim University, Buraydah, Saudi Arabia
Abstract
Funder
Qassim University
Publisher
Georg Thieme Verlag KG
Subject
Organic Chemistry,Complementary and alternative medicine,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Analytical Chemistry
Link
http://www.thieme-connect.de/products/ejournals/pdf/10.1055/a-1582-9794.pdf
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3. Organic cation transporter 1 mediates the uptake of monocrotaline and plays an important role in its hepatotoxicity;M Tu;Toxicology,2013
4. The SLC22 drug transporter family;H Koepsell;Pflügers Archiv,2004
5. Involvement of organic cation transporter 1 and CYP3A4 in retrorsine-induced toxicity;M Tu;Toxicology,2014
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